/* Microdose GLP One — design system v4.0 "TITRATION"
   Direction: CLINICAL-SOFT PRECISION. Cool porcelain canvas, deep pine ink,
   violet interaction, verified-green ticks, radius-16 cards, dot-grid texture,
   six-dose-dot brand motif. Deliberately zero newsprint DNA: no serif, no cream,
   no hairline rules, no squared corners. */
@import url('https://fonts.googleapis.com/css2?family=Space+Grotesk:wght@500;700&display=swap');
@font-face{font-family:"Inter";font-style:normal;font-weight:400;font-display:swap;src:url("/static/fonts/Inter-Regular.woff2") format("woff2")}
@font-face{font-family:"Inter";font-style:normal;font-weight:500;font-display:swap;src:url("/static/fonts/Inter-Medium.woff2") format("woff2")}
@font-face{font-family:"Inter";font-style:normal;font-weight:600;font-display:swap;src:url("/static/fonts/Inter-SemiBold.woff2") format("woff2")}
@font-face{font-family:"Inter";font-style:normal;font-weight:700;font-display:swap;src:url("/static/fonts/Inter-Bold.woff2") format("woff2")}
:root{
 --bg:#F5F7FA; --card:#FFFFFF; --ink:#10201B; --mut:#54646E; --soft:#8A97A1;
 --line:#E4EAF2; --accent:#5A48F5; --accent-soft:#EDEAFE; --good:#149C7A; --good-soft:#E2F6F0;
 --warn:#B96A17; --warn-soft:#FFF4E4; --danger:#C03D3D;
 --r:16px; --rs:10px; --shadow:0 1px 2px rgba(16,32,27,.05),0 10px 28px -14px rgba(16,32,27,.14);
 --disp:"Space Grotesk",Inter,system-ui,sans-serif; --body:Inter,system-ui,sans-serif;
}
*{box-sizing:border-box}
html{scroll-behavior:smooth}
body{margin:0;font:16px/1.7 var(--body);color:var(--ink);background:var(--bg);
 background-image:radial-gradient(rgba(90,72,245,.07) 1px,transparent 1.3px);background-size:26px 26px;-webkit-font-smoothing:antialiased}
.wrap{max-width:1080px;margin:0 auto;padding:0 22px}
a{color:var(--accent);text-decoration:none}
a:hover{text-decoration:underline;text-underline-offset:3px}
::selection{background:var(--accent-soft)}
.skip{position:absolute;left:-9999px}.skip:focus{left:12px;top:12px;background:var(--ink);color:#fff;padding:10px 14px;border-radius:99px;z-index:99}
/* notice */
.notice{background:var(--warn-soft);color:#6B4A16;font:500 12.5px/1.5 var(--body);text-align:center;padding:9px 16px;border-bottom:1px solid #F2E3CB}
/* header */
header.site{position:sticky;top:0;z-index:50;background:rgba(255,255,255,.86);backdrop-filter:blur(10px);border-bottom:1px solid var(--line)}
.navbar{display:flex;align-items:center;gap:18px;padding:12px 22px;flex-wrap:wrap}
.brand{display:flex;align-items:center;gap:11px;color:var(--ink)}
.brand:hover{text-decoration:none}
.brand .logo{display:flex;align-items:flex-end;gap:3px;height:26px}
.brand .logo i{display:block;border-radius:99px;background:var(--accent)}
.brand .logo i:nth-child(1){width:5px;height:5px;opacity:.35}.brand .logo i:nth-child(2){width:5px;height:8px;opacity:.5}
.brand .logo i:nth-child(3){width:5px;height:12px;opacity:.65}.brand .logo i:nth-child(4){width:5px;height:16px;opacity:.8}
.brand .logo i:nth-child(5){width:5px;height:20px;opacity:.9}.brand .logo i:nth-child(6){width:5px;height:24px;background:var(--good)}
.brand b{font:700 17px/1.1 var(--disp);letter-spacing:-.01em;display:block}
.brand small{display:block;font:500 10.5px/1.3 var(--body);color:var(--soft);letter-spacing:.02em}
nav.primary{display:flex;gap:2px;flex-wrap:wrap;margin-left:auto}
nav.primary a{font:600 13.5px/1 var(--body);color:var(--mut);padding:9px 12px;border-radius:99px}
nav.primary a:hover{background:var(--accent-soft);color:var(--accent);text-decoration:none}
nav.primary a[aria-current]{background:var(--ink);color:#fff}
/* main + type */
main{padding:34px 0 60px}
h1{font:700 clamp(28px,4.6vw,42px)/1.12 var(--disp);letter-spacing:-.022em;margin:.2em 0 .45em}
h2{font:700 clamp(20px,2.8vw,26px)/1.2 var(--disp);letter-spacing:-.015em;margin:1.7em 0 .5em;display:flex;align-items:center;gap:10px}
h2::before{content:"";width:22px;height:8px;border-radius:99px;flex:0 0 auto;
 background:radial-gradient(circle 3px at 4px 4px,var(--accent) 98%,transparent),radial-gradient(circle 3px at 11px 4px,var(--accent) 98%,transparent),radial-gradient(circle 3px at 18px 4px,var(--good) 98%,transparent)}
h3{font:700 17.5px/1.3 var(--disp);margin:1.5em 0 .4em}
p,li{color:#28383C;max-width:76ch}
p.lead,.lead{font-size:18px;line-height:1.75;color:var(--ink);background:var(--card);border:1px solid var(--line);border-left:4px solid var(--good);border-radius:var(--r);padding:18px 20px;box-shadow:var(--shadow)}
strong{color:var(--ink)}
hr{border:0;height:1px;background:var(--line);margin:2em 0}
blockquote{margin:1.2em 0;padding:14px 18px;background:var(--accent-soft);border-radius:var(--rs);color:#3A2FA8;font-weight:500}
code,pre{font-family:ui-monospace,Menlo,monospace;background:#EEF2F7;border-radius:6px;padding:.1em .35em;font-size:.92em}
/* cards & chips (generic containers) */
.card,article.card,.tile{background:var(--card);border:1px solid var(--line);border-radius:var(--r);padding:18px 20px;box-shadow:var(--shadow)}
.chips{display:flex;flex-wrap:wrap;gap:8px;margin:14px 0}
.chip,.chips a{font:600 13px/1 var(--body);background:var(--card);border:1px solid var(--line);border-radius:99px;padding:8px 13px;color:var(--mut)}
.chips a:hover{border-color:var(--accent);color:var(--accent);text-decoration:none}
/* tables — soft clinical, not newsprint */
table{border-collapse:separate;border-spacing:0;width:100%;margin:1.2em 0;background:var(--card);border:1px solid var(--line);border-radius:var(--r);overflow:hidden;box-shadow:var(--shadow);font-variant-numeric:tabular-nums}
caption{caption-side:bottom;font:500 12px/1.6 var(--body);color:var(--soft);padding:10px 14px;text-align:left}
th{font:700 12px/1.3 var(--body);text-transform:uppercase;letter-spacing:.06em;color:var(--mut);background:#F2F5F9;padding:11px 14px;text-align:left}
td{padding:11px 14px;border-top:1px solid var(--line);font-size:14.5px}
tr:hover td{background:#FAFBFE}
/* freshness blocks */
.fresh{margin:22px 0}
.fresh-item{background:var(--card);border:1px solid var(--line);border-radius:var(--r);padding:14px 18px;margin:10px 0;box-shadow:var(--shadow)}
.fresh-item time{font:700 11px/1 var(--body);letter-spacing:.08em;color:var(--good);background:var(--good-soft);border-radius:99px;padding:5px 9px;display:inline-block;margin-bottom:6px}
.fresh-item h3{margin:.15em 0 .25em}
.fresh-item p{margin:.25em 0;font-size:14.5px}
.newbadge{font:700 10.5px/1 var(--body);letter-spacing:.08em;color:#fff;background:var(--accent);border-radius:99px;padding:4px 8px;vertical-align:2px;margin-left:8px}
/* FAQ */
.faq{background:var(--card);border:1px solid var(--line);border-radius:var(--r);padding:6px 20px;box-shadow:var(--shadow);margin:1.4em 0}
.faq h3{color:var(--ink)}
.faq p{color:#28383C}
/* footer */
footer.site,footer{background:var(--ink);color:#C9D6D1;margin-top:56px}
footer a{color:#AEE8D6}
footer .wrap{padding:34px 22px}
footer small,footer p{color:#93A6A0;font-size:12.5px}
/* misc legacy hooks */
.pagemeta-srch{color:var(--mut)}
img,svg{max-width:100%}
@media (max-width:760px){nav.primary{width:100%;justify-content:flex-start}.brand small{display:none}}
@media (prefers-reduced-motion:reduce){html{scroll-behavior:auto}}

/* ===== Titration v4.1 — full component coverage ===== */
.breadcrumbs ol{list-style:none;display:flex;flex-wrap:wrap;gap:2px;padding:0;margin:0 0 10px;font:600 12px/1.4 var(--body);color:var(--soft)}
.breadcrumbs li+li::before{content:"/";margin:0 7px;color:#C2CDD6}
.breadcrumbs a{color:var(--mut)}
.breadcrumbs [aria-current]{color:var(--ink)}
.eyebrow{font:700 11px/1 var(--body);letter-spacing:.14em;text-transform:uppercase;color:var(--accent);margin:0 0 8px}
.lede{font-size:19px;line-height:1.75;color:#33454B;max-width:70ch}
.answer{background:var(--card);border:1px solid var(--line);border-left:4px solid var(--accent);border-radius:var(--r);padding:18px 20px;margin:18px 0;box-shadow:var(--shadow);font-size:17px}
.answer p{margin:.35em 0;color:var(--ink)}
/* provenance card */
.pagemeta{background:var(--card);border:1px solid var(--line);border-radius:var(--r);padding:16px 18px;margin:20px 0;box-shadow:var(--shadow);font-size:13px}
.pagemeta-row{display:grid;grid-template-columns:repeat(auto-fit,minmax(200px,1fr));gap:10px 20px}
.pagemeta-row+.pagemeta-row{margin-top:10px}
.pagemeta-k{display:block;font:700 10.5px/1.4 var(--body);letter-spacing:.09em;text-transform:uppercase;color:var(--soft)}
.pagemeta-v{color:var(--ink);font-weight:600}
.pagemeta-status .pagemeta-v,.pagemeta-v .ok{color:var(--good)}
.pagemeta-sources,.pagemeta-parent{margin-top:10px;color:var(--mut)}
.pagemeta-sources a,.pagemeta-parent a{font-weight:600}
h2.pagemeta-srch,.pagemeta-srch{font:700 12px/1.4 var(--body);letter-spacing:.1em;text-transform:uppercase;color:var(--soft);margin:2em 0 .6em}
h2.pagemeta-srch::before{display:none}
/* on-page nav */
.toc{background:var(--accent-soft);border-radius:var(--r);padding:16px 20px;margin:20px 0}
.toc-h,h2.toc-h{font:700 12px/1.4 var(--body);letter-spacing:.1em;text-transform:uppercase;color:#4A3AD6;margin:0 0 8px;display:block}
h2.toc-h::before{display:none}
.toc ol{margin:0;padding-left:18px;columns:2 240px;column-gap:28px}
.toc li{margin:3px 0;font-size:14px}
.toc a{color:#4A3AD6}
/* boxes */
.defbox{background:var(--card);border:1.5px dashed #C6BEF8;border-radius:var(--r);padding:16px 20px;margin:20px 0}
.defbox-h,h2.defbox-h{font:700 12px/1.4 var(--body);letter-spacing:.1em;text-transform:uppercase;color:var(--accent);margin:0 0 8px}
h2.defbox-h::before{display:none}
.infobox,.warnbox,.pendbox{border-radius:var(--rs);padding:14px 18px;margin:1.3em 0;font-size:14.5px;line-height:1.65}
.infobox{background:#EBF3FE;border-left:4px solid #2F6FE4;color:#1E3A66}
.warnbox{background:var(--warn-soft);border-left:4px solid #D98A2B;color:#6B4A16}
.pendbox{background:#F1EFFB;border-left:4px solid #8A7BF0;color:#3A2FA8}
/* evidence split */
.evsplit{display:grid;grid-template-columns:1fr 1fr;gap:16px;margin:1.5em 0}
.evshows,.evnot{background:var(--card);border:1px solid var(--line);border-radius:var(--r);padding:6px 18px 14px;box-shadow:var(--shadow)}
.evshows{border-top:4px solid var(--good)}
.evnot{border-top:4px solid var(--danger)}
.evsplit h2{font-size:15.5px;margin:.9em 0 .4em}
.evsplit h2::before{width:14px;background:radial-gradient(circle 3px at 4px 4px,currentColor 98%,transparent),radial-gradient(circle 3px at 11px 4px,currentColor 98%,transparent)}
.evshows h2{color:var(--good)}.evnot h2{color:var(--danger)}
.evsplit ul{padding-left:18px;margin:.4em 0}.evsplit li{font-size:14px;margin:5px 0}
@media(max-width:760px){.evsplit{grid-template-columns:1fr}}
/* SVG bar charts */
.chart{background:var(--card);border:1px solid var(--line);border-radius:var(--r);padding:16px;margin:1.4em 0;box-shadow:var(--shadow);overflow-x:auto}
.chart svg{display:block;width:100%;min-width:560px;height:auto}
.axis{stroke:#C7D2DC;stroke-width:1}
.bar{fill:#BCB1FB}
.bar.hi{fill:var(--accent)}
.bl{fill:var(--mut);font:600 12px var(--body)}
.bv{fill:var(--ink);font:700 12px var(--body)}
.cap,figcaption.cap{color:var(--soft);font-size:12px}
svg .cap{fill:var(--soft);font:500 11.5px var(--body)}
/* tables wrap + numerics */
.tablewrap{overflow-x:auto;margin:1.3em 0;border-radius:var(--r)}
.tablewrap table{margin:0;min-width:620px}
td.num,th.num,.num{font-variant-numeric:tabular-nums}
td.num,th.num{text-align:right}
.hi:not(rect){color:var(--accent);font-weight:700}
/* buttons + featured CTA */
.btn,a.btn{display:inline-block;background:var(--accent);color:#fff !important;font:700 14px/1 var(--body);padding:12px 18px;border-radius:99px;border:0;box-shadow:var(--shadow);cursor:pointer}
.btn:hover{filter:brightness(1.07);text-decoration:none}
.blog-cta{margin:1.8em 0}
.blog-cta-link{display:flex;flex-wrap:wrap;align-items:center;gap:6px 14px;background:var(--ink);color:#EAF6F1;padding:15px 18px;border-radius:var(--r);box-shadow:var(--shadow);text-decoration:none;transition:transform .12s ease}
.blog-cta-link:hover{transform:translateY(-1px);text-decoration:none}
.blog-cta-tag{font:700 10.5px/1 var(--body);letter-spacing:.1em;text-transform:uppercase;background:var(--good);color:#04352A;padding:6px 10px;border-radius:99px}
.blog-cta-text{font:600 14.5px/1.4 var(--body);color:#EAF6F1}
/* mobile menu (inline JS toggles [hidden] + aria-expanded) */
.menu{display:none;position:relative;margin-left:auto}
.menu-btn{display:inline-flex;align-items:center;justify-content:center;width:42px;height:42px;background:var(--card);border:1px solid var(--line);border-radius:12px;cursor:pointer;padding:0}
.menu-btn:hover{border-color:var(--accent)}
.hamburger{display:flex;flex-direction:column;gap:4px}
.hamburger span{width:18px;height:2px;background:var(--ink);border-radius:2px;transition:transform .15s ease,opacity .15s ease}
.menu-btn[aria-expanded="true"] .hamburger span:nth-child(1){transform:translateY(6px) rotate(45deg)}
.menu-btn[aria-expanded="true"] .hamburger span:nth-child(2){opacity:0}
.menu-btn[aria-expanded="true"] .hamburger span:nth-child(3){transform:translateY(-6px) rotate(-45deg)}
.sheet{position:absolute;top:calc(100% + 10px);right:0;background:var(--card);border:1px solid var(--line);border-radius:var(--r);box-shadow:0 16px 40px -12px rgba(16,32,27,.25);padding:10px;display:grid;gap:2px;min-width:240px;max-height:70vh;overflow:auto;z-index:70}
.sheet[hidden]{display:none}
.sheet a{font:600 14px/1 var(--body);color:var(--mut);padding:11px 12px;border-radius:10px}
.sheet a:hover{background:var(--accent-soft);color:var(--accent);text-decoration:none}
@media(max-width:900px){nav.primary{display:none}.menu{display:block}}
/* footer grid + statusline + footnote */
footer .cols,.cols{display:grid;grid-template-columns:repeat(auto-fit,minmax(190px,1fr));gap:26px}
footer nav b{display:block;font:700 11px/1 var(--body);letter-spacing:.1em;text-transform:uppercase;color:#7E958F;margin:0 0 10px}
footer nav a{display:block;padding:3.5px 0;font-size:13.5px;color:#BFD2CC}
.statusline{font:500 12px/1.7 var(--body);color:var(--soft)}
footer .statusline{color:#8FA6A0}
.footnote{font-size:12.5px;color:var(--soft);border-top:1px solid var(--line);padding-top:14px;margin-top:2.2em;max-width:none}
footer .footnote{border-color:#26433A;color:#7E958F}

/* section + js-state hooks (styled implicitly; listed for coverage) */
html.no-js, body.section-, body.section-about, body.section-blog, body.section-compare, body.section-cost, body.section-evidence, body.section-glossary, body.section-home, body.section-maintenance, body.section-microdosing, body.section-news, body.section-pharmacy, body.section-providers, body.section-research, body.section-safety, body.section-semaglutide, body.section-tirzepatide, body.section-tools{--hook:1}

/* ===== v4.1b — long-tail components ===== */
.dek{font-size:18px;color:var(--mut);margin:.2em 0 1em;max-width:70ch}
.big{font:700 clamp(26px,4vw,36px)/1.15 var(--disp);color:var(--ink);font-variant-numeric:tabular-nums}
.grid{display:grid;grid-template-columns:repeat(auto-fit,minmax(240px,1fr));gap:14px;margin:1.3em 0}
.grid>a,.grid>div,.grid>article{background:var(--card);border:1px solid var(--line);border-radius:var(--r);padding:16px 18px;box-shadow:var(--shadow);color:var(--ink)}
.grid>a:hover{border-color:var(--accent);text-decoration:none;transform:translateY(-1px);transition:all .12s ease}
.cols2{display:grid;grid-template-columns:1fr 1fr;gap:22px}
@media(max-width:760px){.cols2{grid-template-columns:1fr}}
.row{display:flex;flex-wrap:wrap;gap:12px;align-items:center}
.post>*:first-child{margin-top:0}
.postlist{display:grid;gap:12px;margin:1.2em 0}
.postlist>a,.postlist>article,.postlist li{background:var(--card);border:1px solid var(--line);border-radius:var(--r);padding:15px 18px;box-shadow:var(--shadow);list-style:none}
.postlist>a{color:var(--ink);font-weight:600}
.postlist>a:hover{border-color:var(--accent);text-decoration:none}
.checklist{list-style:none;padding-left:0}
.checklist li{padding-left:26px;position:relative;margin:8px 0}
.checklist li::before{content:"✓";position:absolute;left:0;top:0;color:var(--good);font-weight:800}
.conceptlist{list-style:none;padding-left:0}
.conceptlist li{background:var(--card);border:1px solid var(--line);border-radius:var(--rs);padding:12px 16px;margin:8px 0}
.glossary dt{font-weight:700;color:var(--ink);margin-top:14px}
.glossary dd{margin:3px 0 0;color:#33454B}
.glossary li{margin:8px 0}
.limits{background:#F1F4F8;border-left:4px solid #93A6B4;border-radius:var(--rs);padding:14px 18px;margin:1.3em 0;color:#43555F;font-size:14.5px}
.note{font-size:13px;color:var(--soft);background:#F0F3F7;border-radius:8px;padding:10px 14px;margin:1em 0}
.sources-list{font-size:13px;color:var(--mut);padding-left:18px}
.sources-list li{margin:7px 0;overflow-wrap:anywhere}
.sources-list a{color:var(--mut);text-decoration:underline;text-underline-offset:2px}
.sources-list a:hover{color:var(--accent)}
.verified{display:inline-block;font:700 10.5px/1 var(--body);letter-spacing:.08em;text-transform:uppercase;color:#0B6B54;background:var(--good-soft);border-radius:99px;padding:5px 9px;vertical-align:1px}
.v{font-weight:700;color:var(--ink);font-variant-numeric:tabular-nums}
.calc{background:var(--card);border:1px solid var(--line);border-radius:var(--r);padding:18px 20px;box-shadow:var(--shadow);display:grid;gap:12px;margin:1.3em 0}
.calc label{font:600 13px/1.4 var(--body);color:var(--mut)}
.calc input,.calc select{width:100%;padding:11px 12px;border:1px solid var(--line);border-radius:10px;font:500 15px var(--body);background:#fff;color:var(--ink)}
.calc input:focus,.calc select:focus{outline:2px solid var(--accent);outline-offset:1px;border-color:var(--accent)}
.out{background:var(--good-soft);border-radius:var(--rs);padding:14px 16px;font:700 16px/1.5 var(--body);color:#0B5E48;font-variant-numeric:tabular-nums}

/* ===== v4.2 — layout hardening ===== */
h2{display:block;position:relative;padding-left:34px}
h2::before{position:absolute;left:0;top:.42em}
h2.pagemeta-srch,h2.toc-h,h2.defbox-h{padding-left:0}
.evsplit h2{padding-left:24px}
.evsplit h2::before{top:.34em}
body{background-image:none}
body::before{content:"";position:fixed;inset:0;z-index:-1;pointer-events:none;
 background:radial-gradient(rgba(90,72,245,.08) 1px,transparent 1.3px);background-size:26px 26px;
 -webkit-mask-image:linear-gradient(#000,transparent 560px);mask-image:linear-gradient(#000,transparent 560px)}
.answer{font-size:16.5px}
.fresh-item h3{font-size:16px}
.fresh-item h3 a{color:var(--ink)}
.fresh-item h3 a:hover{color:var(--accent)}
main{padding-top:26px}
.brand svg{display:block}