Compounded medications are not FDA approved. FDA does not review compounded medications for safety, effectiveness, or quality before they are marketed.
Microdose GLP OneEvidence Edition · Updated July 20, 2026

Off-ramping

GLP-1 tapering and off-ramping

What the withdrawal evidence shows — and why there is no universal off-ramp schedule.

There is no evidence-based universal schedule for tapering off a GLP-1. Withdrawal trials show weight tends to return after stopping, whether stopped abruptly or not. Any taper is an individual, clinician-supervised decision — this page explains the evidence gaps rather than providing a schedule.

What the evidence shows

  • Withdrawal trials (STEP 4, SURMOUNT-4) show weight regain after discontinuation.
  • Continued therapy preserves more of the response than stopping.

What the evidence does not show

  • That a specific taper prevents weight regain.
  • That any universal off-ramp schedule is safe or effective — none is established.
No schedule here. We do not publish a tapering or off-ramping schedule. Reducing or stopping a prescription is a decision to make with your prescriber.

Frequently asked questions

How do I taper off a GLP-1?

There is no universal schedule, and we don't provide one. It's an individual decision with your prescriber; the evidence shows weight tends to return after stopping.

Does tapering prevent weight regain?

Unproven. Withdrawal trials show regain after stopping; a specific taper has not been shown to prevent it.

Not medical advice. This page is consumer education, not medical advice, and does not recommend a dose, product, or provider. Compounded medications are not FDA approved. Talk with a licensed clinician about your situation.