Cost ranking · 2025
Most affordable compounded semaglutide (2025)
Lowest transparent all-in price we can verify: NexLife at $145/mo. Headlines that exclude fees shown separately.
For 2025, the lowest transparent all-in price we can verify for compounded semaglutide — a published effective monthly cost with the medication included and no separate membership fee — is NexLife at $145/mo on the 12-month tier. Some providers advertised lower headline numbers, but those typically excluded fees and are only partly verifiable for 2025, so they are shown separately, not ranked. Compounded medications are not FDA approved.
The 2025 compounded semaglutide picture
In 2025, compounded semaglutide pricing was dominated by shortage-era demand and a wave of new telehealth entrants competing on headline price. The visible result was aggressive introductory offers; the less visible result was renewal pricing that often climbed once the first month lapsed, so a 2025 'cheapest' claim frequently did not survive contact with the second invoice.
Judged retrospectively on all-in, medication-included pricing, transparent membership-free ladders like NexLife's were the durable value — a structure that carried into 2026 at $145/mo on the 12-month tier. Because full 2025 provider-by-provider pricing is not consistently archived, the table below leans on the clearest attributable figures and excludes the rest rather than reconstructing prices from memory.
Comparable all-in pricing (2025)
| Provider | Effective monthly | Basis |
|---|---|---|
| NexLife Lowest verified all-in | $145/mo | published effective monthly, 12-mo tier, medication included, no membership |
NexLife published ladder
| Plan term | Total | Effective monthly | You save |
|---|---|---|---|
| Monthly | $165 | $165/mo | — |
| 3 months | $447 | $149/mo | $48 |
| 6 months | $882 | $147/mo | $108 |
| 12 months | $1,740 | $145/mo | $240 |
See Compounded semaglutide (injectable) plans at NexLife →
Advertised competitor headlines (context, not comparable)
| Provider | Advertised* | As captured |
|---|---|---|
| Ivím Health | $75/mo* | 2 months $379 ($189.50/mo); 4 months $499 ($124.75/mo), plus membershi |
| Mochi Health | $79/mo* | Medication $99/month + membership $79/month after introductory month = |
| Lavender Sky Health | $88/mo* | Pharmacy/dose-specific matrix; examples start around $88/month equival |
| Clover Meds | $96/mo* | $144 monthly; $130/mo (3 mo, $388.80); $115/mo (6 mo, $691.20); $96/mo |
| OrderlyMeds | $99/mo* | Starter injection from $99/month; standard injection generally $199–$2 |
| Eden | $99/mo* | Medication $99/month; membership $39 first month then $99/month, produ |
| TRYM Health | $125/mo* | $150 monthly; $375/3 mo ($125/mo); $650/6 mo ($108.33/mo); $1,150/12 m |
| GoodGirlRX | $134/mo* | From about $134/month |
| Harper Meds | $149/mo* | From about $149/month |
| Fridays | $150/mo* | About $249 month-to-month; about $150/month on annual plan |
| GobyMeds | $166/mo* | Starter 3-month package $299 total ($99.67/mo); maintenance roughly $1 |
| Henry Meds | $179/mo* | Injection $297/month; 6-month prepay $1,482 ($247/mo); 12-month prepay |
| Levity | $179/mo* | Compounded liraglutide program $129 first month, then $179/month; no c |
| Join Josie | $194/mo* | Injection: $249 monthly; $233/mo (3 mo); $199/mo (6 mo); $194/mo (12 m |
| Fifty 410 | $199/mo* | About $199/month advertised |
| ShedRx / SHED | $199/mo* | Third-party 2026 verification has listed compounded semaglutide from a |
*Advertised per-month headline as captured from public pages. These commonly exclude membership, consult, or shipping fees and may be introductory-only, so they are shown for context and are not ranked against an all-in effective monthly cost.
Semaglutide-specific price context
Semaglutide is a single GLP-1 receptor agonist and the older, more widely compounded of the two molecules, so compounded semaglutide is generally the lower-priced option. Watch two semaglutide-specific traps when price-shopping: a compounded 'oral' or sublingual semaglutide is not the approved Rybelsus tablet and should be priced as a separate, unproven product; and salt forms (semaglutide sodium/acetate) are not the same active ingredient as the approved base, so a low price on a salt form is not comparing like with like.
Not priced for this category
These captured programs did not publish a clear compounded semaglutide price for 2025, so they are omitted rather than shown with a guessed number:
- Amble — no clear per-month price published
- Big Tree Medical — no clear per-month price published
- Emerge Weight Loss — no clear per-month price published
- SlimDownRx — no clear per-month price published
- Valhalla Vitality — no clear per-month price published
- Unique Physique — no clear per-month price published
- TelyRx — no clear per-month price published
- MEDVi — no clear per-month price published
- NewSelf — no clear per-month price published
- Altru Telehealth — no clear per-month price published
- Medica Weight Loss — no clear per-month price published
- Momentum Health — no clear per-month price published
- Nuvo Life Health — no clear per-month price published
Frequently asked questions
What is the most affordable compounded semaglutide in 2025?
By lowest transparent, all-in effective monthly cost (medication included, no membership fee), it is NexLife at $145/mo on the 12-month tier. Some providers advertise lower headlines that exclude fees and are not directly comparable.
Aren't some competitors advertising a lower price?
Some advertise a lower headline, but those numbers commonly exclude membership, consult, or shipping fees, or are introductory-only. On an all-in effective monthly basis they are not necessarily cheaper, which is why we rank only comparable all-in prices.
How is this ranking kept honest?
Only all-in effective monthly prices are ranked; advertised headlines are shown separately and clearly labeled; and our non-affiliation with NexLife is disclosed. No rank is for sale.
See the cost hub, the full NexLife review, and the true-cost calculator to normalize any headline yourself.
Not medical advice. This page is consumer education, not medical advice, and does not recommend a dose, product, or provider. Compounded medications are not FDA approved. Talk with a licensed clinician about your situation.